When cells proliferate, genomic DNA is precisely duplicated once per cell cycle. Abnormalities in this DNA replication ...

Our lab studies the mechanism of eukaryotic chromosome replication. Chromosomes are the carriers of the genetic and epigenetic information and faithful chromosome replication is of fundamental ...

The universal features that define genomic regions acting as replication origins remain unclear. In this study, we mapped a set of origins in Trypanosoma brucei using stranded short nascent strand ...

The research published in Nature on Dec. 25th, 2019, led by Dr. LI Guohong and Dr. ZHU Mingzhao from the Institute of Biophysics of the Chinese Academy of Sciences, has demonstrated that the histone ...

The genetic connections between DNA repair pathways and human cancer predisposition have fueled interest in the proteins that recognize and repair specific sites of DNA damage. The repair enzymes are ...

Nuclear-encoded regulatory proteins control mitochondrial translation. A few, however, are encoded by the mitochondrial DNA (mtDNA) and are produced by the mitochondrial translation machinery.